Dren Bio Logo
dren's logo

Robust depletion of disease-causing cells and agents

Dren’s team has profound expertise in antibody executed elimination of pathological cells

We selectively engage an effector cell for targeted depletion of diseased cells or agents

The company’s pipeline has two lead programs:

  • DR-01 utilizes antibody-mediated killing of a cell type involved in leukemia, lymphomas and autoimmune diseases


  • Initially targeting neglected HemOnc indications with no approved therapies
  • Expansion into defined subsets of autoimmune diseases
monocyte cell

  • DR-02 is an enhanced antibody-based platform for depletion of cells and disease-inducing agents through a novel MOA


  • Potential applications in solid tumors, hematologic neoplasms, infectious diseases and protein aggregate diseases
  • A proprietary monotherapy with multiple modes of action
    • Direct depletion
    • Immune stimulation
    • Target engagement
    • Antigen presentation

Leadership

Board of Directors and Investors

Alexandria Venture Investments

Scientific Advisory Board

Careers

Senior GL Accountant


Position:

Senior GL Accountant

About the Company:

Dren Bio (the “Company”) is a privately held, pre-clinical stage biopharmaceutical company focused on developing therapeutic antibodies for the treatment of cancer, autoimmune and other serious diseases. The Company’s management team and scientific advisors have profound expertise covering the discovery and development of engineered antibodies designed to selectively target and deplete pathological cells. Dren Bio’s pipeline is currently comprised of two distinct drug discovery programs. The Company’s first program surrounds DR-01, its lead product candidate, which induces antibody-mediated killing of a cell type that is responsible for a multitude of hematologic malignancies and plays a key role in various autoimmune diseases. The Company’s second program surrounds its Targeted Myeloid Engager and Phagocytosis Platform, a proprietary bispecific antibody-based technology that provides a novel mechanism of action to selectively engage myeloid cells for (1) targeted depletion of pathologic cells and other disease-inducing agents and (2) inducing localized immunostimulation. The engagement of antigen presenting cells has the potential to elicit a sustained, durable response.

Function:

Finance

Level:

Senior Accountant

Location:

Redwood City, CA

Reporting Manager:

Corporate Controller

About the Opportunity:

The Senior GL Accountant is a newly created role for the Dren Bio Accounting Team that initially report to the Corporate Controller. In this role, you will utilize your technical accounting expertise to support and lead parts of the monthly financial statement close, manage a future Staff Accountant to be hired, fixed assets, accounts payable processes, annual audit, financial systems, accounting policies, procedures, and controls. You will have significant interaction with other operational stakeholders across the organization.

Role and Responsibilities:
  • Responsible for oversight of the accounting operations with an understanding of the application of GAAP, review of accounting transactions, account reconciliations, and maintenance of internal controls, and accounting policies

  • Assist with the day-to-day, monthly, quarterly and year-end operations of the accounting and finance organization, including close processes

  • Manage key components of the monthly and quarterly close processes, including accounts payable, cash, accruals and fixed assets

  • Create and maintain a master list of monthly journal entries, as well as ensure that all related entries are recorded and have appropriate support

  • Monitor, collect and analyze data to assess accuracy and integrity as well as ensure compliance with U.S. GAAP and established policies and procedures

  • Maintain accounting controls by preparing and recommending policies and procedures. Ensure compliance with the financial procedures of the organization and documentation of complex financial transactions.

  • Guide accounting staff by coordinating activities and answering questions.

  • Assist in managing travel & expense reimbursement processes

  • Assist in the preparation for audit including verification of transactions; ensure adequate documentation and preparation of schedules.

  • Assist with projects for process, control, and scalability improvements including documentation of the control environment.

  • Other projects as assigned

Education, Experience and Qualification Requirements:
  • 4 years of experience at an accounting firm, public company or venture-backed startup

  • CPA with working knowledge of US GAAP preferred

  • Experience building processes and systems

  • Experience managing team members

  • Experience in the life science industry

Core Competencies, Knowledge and Skill Requirements:
  • Experience with financial reporting systems (Netsuite, Blackline & Bill.com preferred)

  • Experience preparing detailed analytical and quantitative analysis

  • Team player with excellent communication skills

  • Effective project management and organization skills

  • Cross-functional flexibility to support strategic projects, as well as systems and process enhancements

Salaries, Benefits and Other Employee Perks:

Dren Bio strongly believes in investing in, and rewarding, its employees. This philosophy is embodied in the Company’s total rewards program, which includes competitive cash compensation, equity incentive awards, and employer sponsored benefit offerings. Exact cash and equity compensation shall be commensurate with candidate’s experience and qualifications.

Employment Practices:

Dren Bio is an equal opportunity employer. Employment decisions are based on merit and business needs. Dren Bio will not discriminate against any job applicant because of race, color, national origin, ancestry, gender, sexual orientation, age, religion, creed, physical or mental disability, gender identity, medical condition, pregnancy, marital status, veteran status, or any other characteristic protected by federal, state or local law.

Interested Applicants:

Please send resume and cover letter to careers@drenbio.com

PDF Version

Scientist II, Senior Scientist, or Principal Scientist


Position:

Scientist II, Senior Scientist, or Principal Scientist

About the Company:

Dren Bio (the “Company”) is a privately held, pre-clinical stage biopharmaceutical company focused on developing therapeutic antibodies for the treatment of cancer, autoimmune and other serious diseases. The Company’s management team and scientific advisors have profound expertise covering the discovery and development of engineered antibodies designed to selectively target and deplete pathological cells. Dren Bio’s pipeline is currently comprised of two distinct drug discovery programs. The Company’s first program surrounds DR-01, its lead product candidate, which induces antibody-mediated killing of a cell type that is responsible for a multitude of hematologic malignancies and plays a key role in various autoimmune diseases. The Company’s second program surrounds its Targeted Myeloid Engager and Phagocytosis Platform, a proprietary bispecific antibody-based technology that provides for a novel mechanism of action to selectively engage myeloid cells for (1) targeted depletion of pathologic cells and other disease-inducing agents and (2) inducing localized immunostimulation. The engagement of antigen presenting cells has the potential to elicit a sustained, durable response.

Function:

Biologics Discovery

Level:

Senior Scientist, or Principal Scientist based on experience

Location:

Redwood City, CA

Reporting Manager:

Associate Director, Biologics Discovery

About the Opportunity:

Dren Bio is seeking a bright, highly motivated, and experienced scientist to join the Biologics Group. The Biologics group is responsible for various functions critical for drug development such as: antibody discovery, molecular biology, cell line engineering, protein engineering, biophysical analytics, and functional cell assays. This position will need to bridge biology and protein understanding to drive projects from early exploratory work to clinical POC for the myeloid engager platform in a cross-functional team of scientists.

Role and Responsibilities:
  • Lead protein engineering efforts, demonstrating flexibility, and enthusiasm to support evolving company goals that are inherent of a fast paced startup environment

  • Collaborate with project team to drive POC experiments, and develop MOA understanding for drug candidate.

  • Present updates and novel concepts to the wider team.

  • Contribute to patents and publications.

  • Strong analytical and critical thinking skills with the ability to interpret complex data and highly motivated to learn and support the drug development efforts

  • Routine literature search and keeping up to date of the competitive landscape of immunooncology, and various moieties being designed as next generation drugs.

  • Motivated self starter who can work independently and collaboratively in a dynamic team environment with a proactive attitude

  • Excellent written and verbal communication skills

  • Ability to work in a fast paced environment and the flexibility to align daily work with project needs

  • Ability to set goals and prioritize tasks and resources to achieve superior work quality and efficiency

  • Must be well organized, have a strong work ethic, attention to detail and be diligent in data documentation

Education, Experience and Qualification Requirements:
  • Bachelors or Masters in immunology, molecular biology, or related field (10+ years of experience)

  • PhD in Cancer Biology, Biochemistry, or related discipline with approximately 0-5 years of experience in academia or biopharmaceutical industry.

  • Demonstrated record of scientific know how and accomplishments (publication and patents)

Core Competencies, Knowledge and Skill Requirements:
  • Understanding of structure-function protein relationship to guide protein engineering

  • Antibody discovery (animal immunization, phage and/or yeast display)

  • Protein chemistry (mol. biology, expression, purification, biophysical analytics)

  • Analytical characterization of antibody based moieties (SEC, HPLC, CE-SDS, Biosensor)

  • Ability analyze protein via structures and sequences. (Pymol, MOE, Schrodinger, ect)

  • Optimize lead antibody candidates (affinity maturation, structure guided design, or in silico analysis)

  • Understanding of immune related assays (ADCC, ADCP, antigen presentation, T Cell activation, ect)

Salaries, Benefits and Other Employee Perks:

Dren Bio strongly believes in investing in, and rewarding, its employees. This philosophy is embodied in the Company’s total rewards program, which includes competitive cash compensation, equity incentive awards, and employer sponsored benefit offerings. Exact cash and equity compensation shall be commensurate with candidate’s experience and qualifications.

Employment Practices:

Dren Bio is an equal opportunity employer. Employment decisions are based on merit and business needs. Dren Bio will not discriminate against any job applicant because of race, color, national origin, ancestry, gender, sexual orientation, age, religion, creed, physical or mental disability, gender identity, medical condition, pregnancy, marital status, veteran status, or any other characteristic protected by federal, state or local law.

Interested Applicants:

Please send resume and cover letter to careers@drenbio.com

PDF Version

Manager, Program Management


About the Company:

Dren Bio (the “Company”) is a privately held, pre-clinical stage biopharmaceutical company focused on developing therapeutic antibodies for the treatment of cancer, autoimmune and other serious diseases. The Company’s management team and scientific advisors have profound expertise covering the discovery and development of engineered antibodies designed to selectively target and deplete pathological cells. Dren Bio’s pipeline is currently comprised of two distinct drug discovery programs. The Company’s first program surrounds DR-01, its lead product candidate, which induces antibody-mediated killing of a cell type that is responsible for a multitude of hematologic malignancies and plays a key role in various autoimmune diseases. The Company’s second program surrounds its Targeted Myeloid Engager and Phagocytosis Platform, a proprietary bispecific antibody-based technology that provides a novel mechanism of action to selectively engage myeloid cells for (1) targeted depletion of pathologic cells and other disease-inducing agents and (2) inducing localized immunostimulation. The engagement of antigen presenting cells has the potential to elicit a sustained, durable response.

Function:

Program Management

Level:

Manager

Location:

Redwood City, CA

Reporting Manager:

Associate Director, Program Management

About the Opportunity:

Dren Bio is seeking a highly motivated Manager to join its Program Management team to drive execution of project, operational, and timeline initiatives and progress the Company’s drug discovery programs. The successful candidate will partner with scientific project lead(s) and cross-functional teams to develop and maintain detailed project plans and ensure timely completion of R&D activities and deliverables associated with the Company’s corporate strategy and objectives. Effective communication, attention to detail, and collaborative leadership skills are essential. This position offers the potential to play a key role in development of Dren’s pipeline projects as well as opportunities for career growth in a fast-paced, dynamic environment.

Role and Responsibilities:
  • Partner with scientific project lead(s) and cross-functional teams to define project objectives, develop plans, budgets and timelines; oversee execution of project plans from discovery through clinical development for multiple indications

  • Monitor and track the project(s) against approved timelines, budgets and milestones; maintain cross functional alignment and accountability to agreed team objectives and deliverables

  • Coordinate and lead project team meetings and/or development strategy meetings, including the creation of meeting agendas, documentation of decisions, action items and issues; liaise across functions to ensure transparency across project team

  • Anticipate project gaps, barriers and risks, identify solutions to proactively respond and develop risk mitigation plans; escalate issues, as appropriate, and join together relevant team members to problem-solve

  • Maintain frequent communication with project team members, key stakeholders, and supervisor to convey project status, risks, progress toward milestones/deliverables, and changes in scope, budget, or timeline

  • Maintain project documentation and accurate records; create and manage project dashboards, trackers, and other project management or productivity tools

  • Build and foster strong working relationships with project team members and key stakeholders to promote effective collaboration and optimal team performance

  • Prepare and monitor financial forecasts

  • Provide administrative support, as needed, including calendaring, RFPs, contract review, logistics

  • Report to and work closely with Associate Director of Program Management to ensure project status, budget and timeline are aligned with corporate objectives, budget, and timeline

Education, Experience and Qualification Requirements:
  • BA/BS or higher degree in life sciences, chemistry, engineering, or equivalent related discipline with 5 years of relevant experience in the biopharmaceutical industry.

  • Prior technical and/or project management experience in drug development is required.

  • PMP certification is a plus.

Core Competencies, Knowledge and Skill Requirements:
  • Team player with high emotional intelligence who is organized, diligent, and thoughtful with outstanding leadership, communication, and project management skills.

  • Skillful use of interpersonal skills and influence to drive results and meet project objectives without formal authority over internal and external team members.

  • Self-directed and proactive with ability to function independently in certain situations, exercise good judgment and respond quickly and effectively to changing environments.

  • Adaptable in the face of uncertainty, responds to unanticipated challenges in a constructive manner and able to generate options for moving forward.

  • Ability to distill, organize, and effectively communicate (verbal and written) key messages from complex discussions and translate strategy into action.

  • Adept at time management and navigating competing and changing priorities in a fast-paced, rapid-growth environment.

  • Technical and/or project management experience in development of a biologic product required.

  • Demonstrated experience building and managing relationships, teams, budgets, and timelines.

  • Experience with conflict resolution, critical thinking, and problem solving in real time.

  • Working knowledge of project management tools; strong computer skills and experience with software such as MS Project, Excel, SharePoint.

  • Adequate knowledge of GxP, US and EU regulations.

  • Understanding of drug research & development phases with emphasis on preclinical and early-stage clinical development.

Salaries, Benefits and Other Employee Perks:

Dren Bio strongly believes in investing in, and rewarding, its employees. This philosophy is embodied in the Company’s total rewards program, which includes competitive cash compensation, equity incentive awards, and employer sponsored benefit offerings. Exact cash and equity compensation shall be commensurate with candidate’s experience and qualifications.

Employment Practices:

Dren Bio is an equal opportunity employer. Employment decisions are based on merit and business needs. Dren Bio will not discriminate against any job applicant because of race, color, national origin, ancestry, gender, sexual orientation, age, religion, creed, physical or mental disability, gender identity, medical condition, pregnancy, marital status, veteran status, or any other characteristic protected by federal, state or local law.

Interested Applicants:

Please send resume and cover letter to careers@drenbio.com

PDF Version

Research Associate II / Senior Research Associate, Biologics Discovery


About the Company:

Dren Bio (the “Company”) is a privately held, pre-clinical stage biopharmaceutical company focused on developing therapeutic antibodies for the treatment of cancer, autoimmune and other serious diseases. The Company’s management team and scientific advisors have profound expertise covering the discovery and development of engineered antibodies designed to selectively target and deplete pathological cells. Dren Bio’s pipeline is currently comprised of two distinct drug discovery programs. The Company’s first program surrounds DR-01, its lead product candidate, which induces antibody-mediated killing of a cell type that is responsible for a multitude of hematologic malignancies and plays a key role in various autoimmune diseases. The Company’s second program surrounds its Targeted Myeloid Engager and Phagocytosis Platform, a proprietary bispecific antibody-based technology that provides for a novel mechanism of action to selectively engage myeloid cells for (1) targeted depletion of pathologic cells and other disease-inducing agents and (2) inducing localized immunostimulation. The engagement of antigen presenting cells has the potential to elicit a sustained, durable response.

Function:

Biologics Discovery

Level:

Research Associate II / Senior Research Associate

Location:

Redwood City, CA

Reporting Manager:

Scientist II, Biologics Discovery

About the Opportunity:

Dren Bio is seeking a bright, highly motivated, and experienced research associate to add to the Biologics Group. The Biologics group is responsible for various functions critical for drug development such as: antibody discovery, molecular biology, cell line engineering, protein expression, protein purification, biophysical analytics, and functional cell assays. Multiple opportunities to cross train and learn additional skills.

Role and Responsibilities:
  • Molecular biology design for protein expression

  • Managing plasmids for expression

  • Transient expression of antibody and antigens in cell systems

  • Characterize purified antibodies in variety of ways (Protein or Cell binding)

  • Preform cell-based experiments to validate protein design concepts

Education, Experience and Qualification Requirements:
  • Bachelors or Masters in biochemistry, molecular biology, or related field

  • Industry experience preferred.

Core Competencies, Knowledge and Skill Requirements:
  • Technical expertise in molecular biology with proficiency in generating constructs for production of antibody and bispecific molecules

  • Transient expression in HEK293 and CHO systems

  • Excellent sterile tissue culture technique for routine maintenance of primary and cancer cell lines and subsequent implementation in cell based assays

  • Good documentation, organization, and communication skills

  • Highly motivated with ability to work collaboratively in a team environment

  • Single color or multi-color flow cytometry

  • Functional protein characterization by ELISA or Octet

  • Primary cell isolation from blood

  • Data processing and analysis software (FlowJo, GraphPad Prism, Geneious)

Salaries, Benefits and Other Employee Perks:

Dren Bio strongly believes in investing in, and rewarding, its employees. This philosophy is embodied in the Company’s total rewards program, which includes competitive cash compensation, equity incentive awards, and employer sponsored benefit offerings. Exact cash and equity compensation shall be commensurate with candidate’s experience and qualifications.

Employment Practices:

Dren Bio is an equal opportunity employer. Employment decisions are based on merit and business needs. Dren Bio will not discriminate against any job applicant because of race, color, national origin, ancestry, gender, sexual orientation, age, religion, creed, physical or mental disability, gender identity, medical condition, pregnancy, marital status, veteran status, or any other characteristic protected by federal, state or local law.

Interested Applicants:

Please send resume and cover letter to careers@drenbio.com

PDF Version

Research Associate II / Senior Research Associate, Analytical & Formulation Development


About the Company:

Dren Bio (the “Company”) is a privately held, pre-clinical stage biopharmaceutical company focused on developing therapeutic antibodies for the treatment of cancer, autoimmune and other serious diseases. The Company’s management team and scientific advisors have profound expertise covering the discovery and development of engineered antibodies designed to selectively target and deplete pathological cells. Dren Bio’s pipeline is currently comprised of two distinct programs. The first program surrounds DR-01, the Company’s lead product candidate, which induces antibody-mediated killing of a cell type that is responsible for a multitude of hematologic malignancies and plays a key role in various autoimmune diseases. The Company’s second program is a proprietary antibody-based technology platform, its Targeted Myeloid Engager, which utilizes a novel mechanism of action to selectively engage myeloid cells for the targeted depletion of diseased cells and disease-inducing agents, as well as to induce immunostimulation.

Function:

Analytical & Formulation Development

Level:

Research Associate II / Senior Research Associate

Location:

Redwood City, CA

Reporting Manager:

Director, Analytical & Formulation Development

About the Opportunity:

Dren Bio is seeking a highly motivated individual to support the protein/antibody characterization needs for all discovery and development for the Company’s pipeline programs. The successful candidate will work as a bench scientist in the Analytical & Formulation Development department and contribute to the analytical method development and formulation needs of the company. This position offers excellent potential for contribution and visibility at an early-stage company and opportunities for career development.

Role and Responsibilities:
  • Routinely run HPLC (SE-HPLC), capillary electrophoresis (Reduced and Non-reduced), icIEF, and ELISA based analytical methods for protein/ antibody characterization.

  • Help develop the above methods for all the molecules in Dren’s pipeline.

  • Work closely with colleagues in Process Sciences to ensure timely analytical support for cell line, process, and formulation development.

  • Facilitate the development of SOPs for various analytical methods and the qualification of methods required for technical transfer to CMO/CRO facilities.

  • Maintain and troubleshoot analytical instrumentation, as required.

  • Troubleshoot assay performance, as needed.

  • Document experimental work in electronic lab notebooks, author SOPs, reports.

  • Communicate results in group meetings.

Education, Experience and Qualification Requirements:
  • Bachelors in Biochemistry, Analytical Chemistry or related discipline with 2+ years of experience in the biotechnology industry; Masters in Biochemistry, Analytical Chemistry or related discipline with 0 - 2+ years of experience in the biotechnology industry.

Core Competencies, Knowledge and Skill Requirements:
  • Hands-on knowledge of technical scientific principles for most of the following analytical techniques: HPLC/UPLC (reverse phase, ion exchange, size exclusion), capillary electrophoresis (reduced and non-reduced CE-SDS), charge heterogeneity (icIEF), ELISAs

  • Strong analytical and critical thinking skills with the ability to interpret obtained results/data

  • Highly motivated to learn and support the drug development efforts at Dren Bio

  • Motivated self-starter who can work independently and collaboratively in a dynamic team environment

  • Excellent written and verbal skills

  • Ability to work in a fast-paced environment and the flexibility to align daily work with project needs

  • Must be well organized, have a strong work ethic with attention to details, and diligent in data documentation.

Salaries, Benefits and Other Employee Perks:

Dren Bio strongly believes in investing in, and rewarding, its employees. This philosophy is embodied in the Company’s total rewards program, which includes competitive cash compensation, equity incentive awards, and employer sponsored benefit offerings. Exact cash and equity compensation shall be commensurate with candidate’s experience and qualifications.

Employment Practices:

Dren Bio is an equal opportunity employer. Employment decisions are based on merit and business needs. Dren Bio will not discriminate against any job applicant because of race, color, national origin, ancestry, gender, sexual orientation, age, religion, creed, physical or mental disability, gender identity, medical condition, pregnancy, marital status, veteran status, or any other characteristic protected by federal, state or local law.

Interested Applicants:

Please send resume and cover letter to careers@drenbio.com

PDF Version

Scientist, Immunology


About the Company:

Dren Bio (the “Company”) is a privately held, pre-clinical stage biopharmaceutical company focused on developing therapeutic antibodies for the treatment of cancer, autoimmune and other serious diseases. The Company’s management team and scientific advisors have profound expertise covering the discovery and development of engineered antibodies designed to selectively target and deplete pathological cells. Dren Bio’s pipeline is currently comprised of two distinct programs. The first program surrounds DR-01, the Company’s lead product candidate, which induces antibody-mediated killing of a cell type that is responsible for a multitude of hematologic malignancies and plays a key role in various autoimmune diseases. The Company’s second program is a proprietary antibody-based technology platform, its Targeted Myeloid Engager, which utilizes a novel mechanism of action to selectively engage myeloid cells for the targeted depletion of diseased cells and disease-inducing agents, as well as to induce immunostimulation.

Function:

Immunology

Level:

Scientist

Location:

Redwood City, CA

Reporting Manager:

Senior Scientist I, Immunology

About the Opportunity:

Dren Bio is seeking a highly talented and motivated scientist to support our Targeted Myeloid Engager platform for the treatment of solid and hematological cancers. The ideal candidate is an expert in macrophage and/or dendritic cell biology with strong technical experience in probing how myeloid cells contribute to disease pathogenesis or could be restored to treat cancer and inflammatory disease. The candidate will work with a cross-functional team of scientists (immunologists, cell biologists, biochemists, and protein engineers) to advance research stage programs into early clinical development. The candidate will be expected to perform essential ex vivo and in vivo studies to not only assess efficacy of our novel therapeutic agents but to elucidate their impact on macrophage and dendritic cell functions in the tumor microenvironment. Importantly, the successful candidate will be provided necessary training, support, and opportunities to grow into and lead a therapeutic program or project sub-teams, and mentor other researchers.

Role and Responsibilities:
  • Work collaboratively with other researchers to advance various therapeutic antibodies in different cancer types

  • Design, conduct, and interpret high quality ex vivo studies (e.g. ADCC, ADCP, cytokine profiling, gene expression profiling) and in vivo studies (e.g. syngeneic, xenograft, and/or humanized mouse models of cancer) to evaluate efficacy and mechanism of action (MOA) of Dren Bio’s novel therapeutic agents

  • Specific tasks include animal or human tissue processing, multi-color flow cytometry for immuno-phenotyping, cytokine profiling by MSD or Luminex, ADCC or ADCP assays using Incucyte live-cell imaging and flow cytometry, IHC/IF and confocal microscopy, DNA/RNA extraction for gene expression studies, various biochemical techniques (IP, western blot, IHC, and IF)

  • Develop and execute assays to evaluate antigen presentation by macrophages and dendritic cells, and T cell activation

  • Well-versed in various data processing and analysis software (e.g. FlowJo, Prism, ImageJ)

  • Mentor and train other scientists on novel tools and techniques

  • Become a project leader for a specific therapeutic program, while demonstrating flexibility and enthusiasm to support evolving company goals that are inherent of a fast-paced start-up environment

  • Meticulous record-keeping of scientific data, methods, and study designs

  • Present data in various forums, including lab meetings, department meetings, and multi-functional project teams

  • Publish scientific and methodological results in high quality journals

Education, Experience and Qualification Requirements:
  • PhD in Immunology, Cancer Biology, Biochemistry, or related discipline with approximately 0-3+ years of experience in academia or biopharmaceutical industry.

Core Competencies, Knowledge and Skill Requirements:
  • The candidate is expected to have in-depth training in immunology and rich technical expertise in cellular and molecular immunology

  • Routine literature search and keeping up to date of the competitive landscape of immuno-oncology

  • Strong expertise in animal or human tissue processing and downstream assays (i.e. immuno-phenotyping by multi-color flow cytometry, immunohistochemistry, cell-based functional assays, biochemical assays)

  • Hands-on experience in designing and executing in vivo studies (e.g. syngeneic, xenograft, PDX, humanized mouse models of immuno-oncology)

  • Proficiency in IP, IV, SC and PO dosing, blood and tissue collection are required

  • Experience with primary cell isolation and culture

  • Must have a record of successful scientific accomplishments as evidenced by one or more first-author papers published or accepted in a well-recognized and peer-reviewed journals

  • Strong analytical and critical thinking skills with the ability to interpret complex data and highly motivated to learn and support the drug development efforts

  • Motivated self-starter who can work independently and collaboratively in a dynamic team environment with a proactive attitude

  • Excellent written and verbal communication skills

  • Ability to work in a fast-paced environment and the flexibility to align daily work with project needs

  • Ability to set goals and prioritize tasks and resources to achieve superior work quality and efficiency

  • Must be well organized, have a strong work ethic, attention to detail and be diligent in data documentation

Salaries, Benefits and Other Employee Perks:

Dren Bio strongly believes in investing in, and rewarding, its employees. This philosophy is embodied in the Company’s total rewards program, which includes competitive cash compensation, equity incentive awards, and employer sponsored benefit offerings. Exact cash and equity compensation shall be commensurate with candidate’s experience and qualifications.

Employment Practices:

Dren Bio is an equal opportunity employer. Employment decisions are based on merit and business needs. Dren Bio will not discriminate against any job applicant because of race, color, national origin, ancestry, gender, sexual orientation, age, religion, creed, physical or mental disability, gender identity, medical condition, pregnancy, marital status, veteran status, or any other characteristic protected by federal, state or local law.

Interested Applicants:

Please send resume and cover letter to careers@drenbio.com.

PDF Version

News

Dren Bio announces a $60M Series A financing

2020-10-16

SAN CARLOS, CA,


Dren Bio, Inc., a company developing powerful protein-engineering technologies for depletion of cells, protein aggregates and other disease-causing agents, announced the closing of a $60 million Series A investment round. The round was led by SR One and Taiho Ventures, LLC , with participation from existing investors 8VC and Mission BioCapital and new investors including BVF Partners L.P., HBM Healthcare Investments, and Alexandria Venture Investments.

Dren will utilize the proceeds to advance its two lead programs through early clinical development. Dren’s first program, DR-01, is an antibody-based therapy to treat rare leukemias and lymphomas as well as specific phenotypes of auto-immune disorders. Dren’s second program, DR-02, is an enhanced antibody-based platform to deplete cells and other disease-causing agents through a novel mechanism-of-action.

"Our strategy is to select the appropriate immune cell type to induce potent and measurable therapeutic effects," said Nenad Tomasevic, PhD, Dren’s Chief Executive Officer and co-founder. "The DR-01 program employs enhanced ADCC to eliminate pathologic cells in clearly defined patient populations. Our DR-02 platform engages a different immune effector cell to a target, resulting in immune stimulation and target depletion."

Dr. Tomasevic brings over twenty years of biotech development experience and previously co-founded Allakos, a clinical-stage, publicly-traded company nearing commercialization.

Lewis Lanier, PhD, Chair of Dren’s Scientific Advisory Board, said, "Dren’s therapies are exciting because they offer novel strategeies to meet an unmet need in treatment of lymphomas and leukemias and to potentially enhance the potency of T cells in cancer immunotherapy." Dr. Lanier is the Chair of Microbiology and Immunology and the J. Michael Bishop MD Distinguished Professor at UCSF.

"We are impressed by Dren’s progress since the company’s inception in 2019," commented Rajeev Dadoo, Partner at SR One. "The DR-01 program has a clear development path to the clinic, focusing on diseases with no approved therapies."

"In oncology, the DR-02 platform could enable direct and selective depletion of cancer cells accompanied by localized immune stimulation," said Sakae Asanuma, President at Taiho Ventures. "The technology is also demonstrating the potential to eliminate agents in diverse diseases, including infections and protein aggregation. We are proud to recognize Dren’s potential at an early stage and support its success."

Dren previously closed a $6 million Seed Financing in 2019 led by 8VC with participation by Mission BioCapital and prominent industry veterans. "We appreciate the support from Dren’s investors,who to date have committed over $66 million in funding for our programs," said John Wesley, co-founder and Chief Financial Officer. "The goal of our Series A financing is to bring two drug candidates to the clinic."

About Dren Bio:

Dren Bio is a San Carlos, CA based biotechnology company developing powerful protein engineering technologies to deplete cells, protein aggregates and other disease-causing agents. Dren’s lead programs are initially focused on hematologic neoplasms and solid cancers. Dren is actively working in other areas including auto-immune disorders and diseases of protein aggregation. Dren’s team includes accomplished research and development personnel with strong collective industry experience. For more information, please visit: https://drenbio.com/.

About SR One

SR One invests globally in emerging life science companies pursuing innovative science to significantly impact medical care. SR One’s team of investment professionals, located in the US and UK, have experience spanning basic science, drug development and commercialization. For more information, please visit: http://www.srone.com/

About Taiho Ventures

Taiho Ventures, LLC is the strategic corporate venture capital arm of Taiho Pharmaceutical Co., Ltd., a Japanese specialty pharma focusing on oncology, allergy and immunology, and urology. Taiho Ventures is looking at early-stage preclinical oncology companies as well as platform technology companies for our core therapeutic areas. Taiho Ventures will review the wide variety of modalities for both biologics and small molecules and also consider the option type of investments and spin-outs, in addition to the pure equity investments. For more information, please visit: https://www.taihoventures.com/

About 8VC

8VC is a leading technology investment firm investing in visionary teams and backing industry-transforming companies. The partners have a proven track-record as founders, engineers, and operators of successful companies including Palantir, Addepar, Affinity and OpenGov, among others. The predecessor firm Formation 8 was founded in 2012 and today, manages $1.1 billion in committed capital. 8VC was founded in 2016 and manages $2.4 billion in committed capital. 8VC invests primarily in SaaS companies and biotechnology. For more information, please visit http://8vc.com.

About BVF Partners L.P.

BVF Partners L.P. is a San Francisco-based investment management firm with more than 26 years investing in public and private biotechnology companies. For more information, please visit: https://www.bvflp.com/

About HBM Healthcare Investments

HBM Healthcare Investments holds and manages an international portfolio of promising companies in the human medicine, biotechnology, medical technology and diagnostics sectors and related areas. HBM Healthcare Investments has an international shareholder base and is listed on SIX Swiss Exchange (ticker: HBMN). For more information, please visit: https://www.hbmhealthcare.com/

About Mission BioCapital

Mission BioCapital (MBC) brings together the teams of Mission Bay Capital and BioInnovation Capital into a single venture firm. MBC is focused on making pivotal, early-stage investments in life science companies. We support entrepreneurs through a unique combination of shared lab spaces, capital investment and access to strategic partners. https://www.missionbiocapital.com/

About Alexandria Venture Investments

Alexandria Venture Investments, founded in 1996, is the strategic venture capital platform of Alexandria Real Estate Equities, Inc. (NYSE:ARE). With more than $1B under management, Alexandria Venture Investments has been recognized by Silicon Valley Bank as the #1 most active investor in biopharma by new deal volume since 2017. Alexandria Venture Investments provides long-term strategic investment capital to transformative seed-, early- and growth-stage life science, technology and agtech companies advancing innovative platforms to improve human health. For more information, please visit www.are.com/venture-investments.html.

CONTACT: Nalin Sar

Dren Bio, Inc.

nsar@drenbio.com

info@drenbio.com

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400 Seaport Ct, Ste 102, Redwood City, CA 94063


Email Address

info@drenbio.com