Careers

Research & Nonclinical Development

About the Company:

Dren Bio (the “Company”) is a privately held, pre-clinical stage biopharmaceutical company focused on developing therapeutic antibodies for the treatment of cancer, autoimmune and other serious diseases. The Company’s management team and scientific advisors have profound expertise covering the discovery and development of engineered antibodies designed to selectively target and deplete pathological cells. Dren Bio’s pipeline is currently comprised of two distinct drug discovery programs. The Company’s first program surrounds DR-01, its lead product candidate, which induces antibody-mediated killing of a cell type that is responsible for a multitude of hematologic malignancies and plays a key role in various autoimmune diseases. The Company’s second program surrounds its Targeted Myeloid Engager and Phagocytosis Platform, a proprietary bispecific antibody-based technology that provides for a novel mechanism of action to selectively engage myeloid cells for (1) targeted depletion of pathologic cells and other disease-inducing agents and (2) inducing localized immunostimulation. The engagement of antigen presenting cells has the potential to elicit a sustained, durable response.

Function:

Biologics Discovery

Level:

Research Associate II / Senior Research Associate

Location:

Foster City, CA

Reporting Manager:

Scientist II, Biologics Discovery

About the Opportunity:

Dren Bio is seeking a bright, highly motivated, and experienced research associate to add to the Biologics Group. The Biologics group is responsible for various functions critical for drug development such as: antibody discovery, molecular biology, cell line engineering, protein expression, protein purification, biophysical analytics, and functional cell assays. Multiple opportunities to cross train and learn additional skills.

Role and Responsibilities:
  • Molecular biology design for protein expression

  • Managing plasmids for expression

  • Transient expression of antibody and antigens in cell systems

  • Characterize purified antibodies in variety of ways (Protein or Cell binding)

  • Preform cell-based experiments to validate protein design concepts

Education, Experience and Qualification Requirements:
  • Bachelors or Masters in biochemistry, molecular biology, or related field

  • Industry experience preferred.

Core Competencies, Knowledge and Skill Requirements:
  • Technical expertise in molecular biology with proficiency in generating constructs for production of antibody and bispecific molecules

  • Transient expression in HEK293 and CHO systems

  • Excellent sterile tissue culture technique for routine maintenance of primary and cancer cell lines and subsequent implementation in cell based assays

  • Good documentation, organization, and communication skills

  • Highly motivated with ability to work collaboratively in a team environment

  • Single color or multi-color flow cytometry

  • Functional protein characterization by ELISA or Octet

  • Primary cell isolation from blood

  • Data processing and analysis software (FlowJo, GraphPad Prism, Geneious)

Salaries, Benefits and Other Employee Perks:

Dren Bio strongly believes in investing in, and rewarding, its employees. This philosophy is embodied in the Company’s total rewards program, which includes competitive cash compensation, equity incentive awards, and employer sponsored benefit offerings. Exact cash and equity compensation shall be commensurate with candidate’s experience and qualifications.

Employment Practices:

Dren Bio is an equal opportunity employer. Employment decisions are based on merit and business needs. Dren Bio will not discriminate against any job applicant because of race, color, national origin, ancestry, gender, sexual orientation, age, religion, creed, physical or mental disability, gender identity, medical condition, pregnancy, marital status, veteran status, or any other characteristic protected by federal, state or local law.

Interested Applicants:

Please send resume and cover letter to careers@drenbio.com

PDF Version
About the Company:

Dren Bio (the “Company”) is a privately held, pre-clinical stage biopharmaceutical company focused on developing therapeutic antibodies for the treatment of cancer, autoimmune and other serious diseases. The Company’s management team and scientific advisors have profound expertise covering the discovery and development of engineered antibodies designed to selectively target and deplete pathological cells. Dren Bio’s pipeline is currently comprised of two distinct programs. The first program surrounds DR-01, the Company’s lead product candidate, which induces antibody-mediated killing of a cell type that is responsible for a multitude of hematologic malignancies and plays a key role in various autoimmune diseases. The Company’s second program is a proprietary antibody-based technology platform, its Targeted Myeloid Engager, which utilizes a novel mechanism of action to selectively engage myeloid cells for the targeted depletion of diseased cells and disease-inducing agents, as well as to induce immunostimulation.

Function:

Immunology

Level:

Scientist

Location:

Foster City, CA

Reporting Manager:

Senior Scientist I, Immunology

About the Opportunity:

Dren Bio is seeking a highly talented and motivated scientist to support our Targeted Myeloid Engager platform for the treatment of solid and hematological cancers. The ideal candidate is an expert in macrophage and/or dendritic cell biology with strong technical experience in probing how myeloid cells contribute to disease pathogenesis or could be restored to treat cancer and inflammatory disease. The candidate will work with a cross-functional team of scientists (immunologists, cell biologists, biochemists, and protein engineers) to advance research stage programs into early clinical development. The candidate will be expected to perform essential ex vivo and in vivo studies to not only assess efficacy of our novel therapeutic agents but to elucidate their impact on macrophage and dendritic cell functions in the tumor microenvironment. Importantly, the successful candidate will be provided necessary training, support, and opportunities to grow into and lead a therapeutic program or project sub-teams, and mentor other researchers.

Role and Responsibilities:
  • Work collaboratively with other researchers to advance various therapeutic antibodies in different cancer types

  • Design, conduct, and interpret high quality ex vivo studies (e.g. ADCC, ADCP, cytokine profiling, gene expression profiling) and in vivo studies (e.g. syngeneic, xenograft, and/or humanized mouse models of cancer) to evaluate efficacy and mechanism of action (MOA) of Dren Bio’s novel therapeutic agents

  • Specific tasks include animal or human tissue processing, multi-color flow cytometry for immuno-phenotyping, cytokine profiling by MSD or Luminex, ADCC or ADCP assays using Incucyte live-cell imaging and flow cytometry, IHC/IF and confocal microscopy, DNA/RNA extraction for gene expression studies, various biochemical techniques (IP, western blot, IHC, and IF)

  • Develop and execute assays to evaluate antigen presentation by macrophages and dendritic cells, and T cell activation

  • Well-versed in various data processing and analysis software (e.g. FlowJo, Prism, ImageJ)

  • Mentor and train other scientists on novel tools and techniques

  • Become a project leader for a specific therapeutic program, while demonstrating flexibility and enthusiasm to support evolving company goals that are inherent of a fast-paced start-up environment

  • Meticulous record-keeping of scientific data, methods, and study designs

  • Present data in various forums, including lab meetings, department meetings, and multi-functional project teams

  • Publish scientific and methodological results in high quality journals

Education, Experience and Qualification Requirements:
  • PhD in Immunology, Cancer Biology, Biochemistry, or related discipline with approximately 0-3+ years of experience in academia or biopharmaceutical industry.

Core Competencies, Knowledge and Skill Requirements:
  • The candidate is expected to have in-depth training in immunology and rich technical expertise in cellular and molecular immunology

  • Routine literature search and keeping up to date of the competitive landscape of immuno-oncology

  • Strong expertise in animal or human tissue processing and downstream assays (i.e. immuno-phenotyping by multi-color flow cytometry, immunohistochemistry, cell-based functional assays, biochemical assays)

  • Hands-on experience in designing and executing in vivo studies (e.g. syngeneic, xenograft, PDX, humanized mouse models of immuno-oncology)

  • Proficiency in IP, IV, SC and PO dosing, blood and tissue collection are required

  • Experience with primary cell isolation and culture

  • Must have a record of successful scientific accomplishments as evidenced by one or more first-author papers published or accepted in a well-recognized and peer-reviewed journals

  • Strong analytical and critical thinking skills with the ability to interpret complex data and highly motivated to learn and support the drug development efforts

  • Motivated self-starter who can work independently and collaboratively in a dynamic team environment with a proactive attitude

  • Excellent written and verbal communication skills

  • Ability to work in a fast-paced environment and the flexibility to align daily work with project needs

  • Ability to set goals and prioritize tasks and resources to achieve superior work quality and efficiency

  • Must be well organized, have a strong work ethic, attention to detail and be diligent in data documentation

Salaries, Benefits and Other Employee Perks:

Dren Bio strongly believes in investing in, and rewarding, its employees. This philosophy is embodied in the Company’s total rewards program, which includes competitive cash compensation, equity incentive awards, and employer sponsored benefit offerings. Exact cash and equity compensation shall be commensurate with candidate’s experience and qualifications.

Employment Practices:

Dren Bio is an equal opportunity employer. Employment decisions are based on merit and business needs. Dren Bio will not discriminate against any job applicant because of race, color, national origin, ancestry, gender, sexual orientation, age, religion, creed, physical or mental disability, gender identity, medical condition, pregnancy, marital status, veteran status, or any other characteristic protected by federal, state or local law.

Interested Applicants:

Please send resume and cover letter to careers@drenbio.com.

PDF Version

Process Sciences & Manufacturing Operations

About the Company:

Dren Bio (the “Company”) is a privately held, pre-clinical stage biopharmaceutical company focused on developing therapeutic antibodies for the treatment of cancer, autoimmune and other serious diseases. The Company’s management team and scientific advisors have profound expertise covering the discovery and development of engineered antibodies designed to selectively target and deplete pathological cells. Dren Bio’s pipeline is currently comprised of two distinct programs. The first program surrounds DR-01, the Company’s lead product candidate, which induces antibody-mediated killing of a cell type that is responsible for a multitude of hematologic malignancies and plays a key role in various autoimmune diseases. The Company’s second program is a proprietary antibody-based technology platform, its Targeted Myeloid Engager, which utilizes a novel mechanism of action to selectively engage myeloid cells for the targeted depletion of diseased cells and disease-inducing agents, as well as to induce immunostimulation.

Function:

Protein Sciences

Level:

Research Associate I

Location:

Foster City, CA

Reporting Manager:

Scientist II, Protein Sciences

About the Opportunity:

Dren Bio is seeking an outstanding, highly motivated individual to support protein production for our discovery programs. The successful candidate will be a member of the Protein Sciences team and support protein production utilizing mammalian protein expression, purification, and characterization. This position offers excellent potential for contribution and visibility at an early-stage company and opportunities for career development. This is a Temp to Hire position.

Role and Responsibilities:
  • As an integral member of the Protein Sciences group, this individual will work closely with other team members and partner with other functional areas in the organization

  • Production of proteins for Research and pre-clinical activities

  • Protein expression in mammalian system in transient and stable format

  • Protein purification using affinity and other chromatography methods

  • Cryopreservation of cell lines and clarification of production medium

  • Protein quantification, SDS-PAGE, size exclusion HPLC, other analytical methods as appropriate

  • Materials management and inventory maintenance

  • Maintenance of electronic lab notebook and databases, preparation of reports, and regular presentations to summarize results and update management

Education, Experience and Qualification Requirements:
  • BS degree in biological sciences (biochemistry, cell biology, molecular biology) with 1-3 years experience in the biopharmaceutical industry

Core Competencies, Knowledge and Skill Requirements:
  • Familiarity with mammalian protein expression systems in transient and stable formats, protein purification of monoclonal antibody and other proteins using affinity and other chromatography techniques

  • Proficiency in aseptic technique, cell line maintenance, and host cell transfection

  • Experience with analytical methods such as SDS-PAGE, size exclusion HPLC, ELISA, Octet and other methods for protein characterization

  • Capacity for learning new techniques and handling diverse tasks concurrently

  • Ability to collaborate and communicate well with colleagues

  • Ability to work independently or with limited direct supervision

  • The ideal candidate will be meticulous, highly organized, pay great attention to detail, deliver consistent results, and work under aggressive timelines

  • The ideal candidate will have strong technical aptitude for lab and instrument work, and a problem-solving mindset that is diligent and flexible

Salaries, Benefits and Other Employee Perks:

Dren Bio strongly believes in investing in, and rewarding, its employees. This philosophy is embodied in the Company’s total rewards program, which includes competitive cash compensation, equity incentive awards, and employer sponsored benefit offerings. Exact cash and equity compensation shall be commensurate with candidate’s experience and qualifications.

Employment Practices:

Dren Bio is an equal opportunity employer. Employment decisions are based on merit and business needs. Dren Bio will not discriminate against any job applicant because of race, color, national origin, ancestry, gender, sexual orientation, age, religion, creed, physical or mental disability, gender identity, medical condition, pregnancy, marital status, veteran status, or any other characteristic protected by federal, state or local law.

Interested Applicants:

Please send resume and cover letter to careers@drenbio.com

PDF Version
About the Company:

Dren Bio (the “Company”) is a privately held, pre-clinical stage biopharmaceutical company focused on developing therapeutic antibodies for the treatment of cancer, autoimmune and other serious diseases. The Company’s management team and scientific advisors have profound expertise covering the discovery and development of engineered antibodies designed to selectively target and deplete pathological cells. Dren Bio’s pipeline is currently comprised of two distinct programs. The first program surrounds DR-01, the Company’s lead product candidate, which induces antibody-mediated killing of a cell type that is responsible for a multitude of hematologic malignancies and plays a key role in various autoimmune diseases. The Company’s second program is a proprietary antibody-based technology platform, its Targeted Myeloid Engager, which utilizes a novel mechanism of action to selectively engage myeloid cells for the targeted depletion of diseased cells and disease-inducing agents, as well as to induce immunostimulation.

Function:

Analytical & Formulation Development

Level:

Research Associate I

Location:

Foster City, CA

Reporting Manager:

Scientist II, Protein Sciences

About the Opportunity:

Dren Bio is seeking a highly motivated individual to support the protein/antibody characterization needs for all discovery and development for the Company’s pipeline programs. The successful candidate will work as a bench scientist in the Analytical & Formulation Development department and contribute to the analytical method development and formulation needs of the company. This position offers excellent potential for contribution and visibility at an early-stage company and opportunities for career development. This is a Temp to Hire position.

Role and Responsibilities:
  • Routinely run HPLC (SE-HPLC), capillary electrophoresis (Reduced and Non-reduced), icIEF, and ELISA based analytical methods for protein/ antibody characterization.

  • Help develop the above methods for all the molecules in Dren’s pipeline.

  • Work closely with colleagues in Process Sciences to ensure timely analytical support for cell line, process, and formulation development.

  • Facilitate the development of SOPs for various analytical methods and the qualification of methods required for technical transfer to CMO/CRO facilities.

  • Maintain and troubleshoot analytical instrumentation, as required.

  • Troubleshoot assay performance, as needed.

  • Document experimental work in electronic lab notebooks, author SOPs, reports.

  • Communicate results in group meetings.

Education, Experience and Qualification Requirements:
  • BS degree in biological sciences (biochemistry, cell biology, molecular biology) with 0-6 months experience in the biopharmaceutical industry

Core Competencies, Knowledge and Skill Requirements:
  • Hands-on knowledge of technical scientific principles for most of the following analytical techniques: HPLC/UPLC (reverse phase, ion exchange, size exclusion), capillary electrophoresis (reduced and non-reduced CE-SDS), charge heterogeneity (icIEF), ELISAs

  • Strong analytical and critical thinking skills with the ability to interpret obtained results/data

  • Highly motivated to learn and support the drug development efforts at Dren Bio

  • Motivated self-starter who can work independently and collaboratively in a dynamic team environment

  • Excellent written and verbal skills

  • Ability to work in a fast-paced environment and the flexibility to align daily work with project needs

  • Must be well organized, have a strong work ethic with attention to details, and diligent in data documentation.

Salaries, Benefits and Other Employee Perks:

Dren Bio strongly believes in investing in, and rewarding, its employees. This philosophy is embodied in the Company’s total rewards program, which includes competitive cash compensation, equity incentive awards, and employer sponsored benefit offerings. Exact cash and equity compensation shall be commensurate with candidate’s experience and qualifications.

Employment Practices:

Dren Bio is an equal opportunity employer. Employment decisions are based on merit and business needs. Dren Bio will not discriminate against any job applicant because of race, color, national origin, ancestry, gender, sexual orientation, age, religion, creed, physical or mental disability, gender identity, medical condition, pregnancy, marital status, veteran status, or any other characteristic protected by federal, state or local law.

Interested Applicants:

Please send resume and cover letter to careers@drenbio.com

PDF Version

Clinical

General & Administrative