Dren Bio (the “Company”) is a privately held, pre-clinical stage biopharmaceutical company focused on developing therapeutic antibodies for the treatment of cancer, autoimmune and other serious diseases. The Company’s management team and scientific advisors have profound expertise covering the discovery and development of engineered antibodies designed to selectively target and deplete pathological cells. Dren Bio’s pipeline is currently comprised of two distinct drug discovery programs. The Company’s first program surrounds DR-01, its lead product candidate, which induces antibody-mediated killing of a cell type that is responsible for a multitude of hematologic malignancies and plays a key role in various autoimmune diseases. The Company’s second program surrounds its Targeted Myeloid Engager and Phagocytosis Platform, a proprietary bispecific antibody-based technology that provides for a novel mechanism of action to selectively engage myeloid cells for (1) targeted depletion of pathologic cells and other disease-inducing agents and (2) inducing localized immunostimulation. The engagement of antigen presenting cells has the potential to elicit a sustained, durable response.
Biologics Discovery
Research Associate II / Senior Research Associate
Foster City, CA
Scientist II, Biologics Discovery
Dren Bio is seeking a bright, highly motivated, and experienced research associate to add to the Biologics Group. The Biologics group is responsible for various functions critical for drug development such as: antibody discovery, molecular biology, cell line engineering, protein expression, protein purification, biophysical analytics, and functional cell assays. Multiple opportunities to cross train and learn additional skills.
Molecular biology design for protein expression
Managing plasmids for expression
Transient expression of antibody and antigens in cell systems
Characterize purified antibodies in variety of ways (Protein or Cell binding)
Preform cell-based experiments to validate protein design concepts
Bachelors or Masters in biochemistry, molecular biology, or related field
Industry experience preferred.
Technical expertise in molecular biology with proficiency in generating constructs for production of antibody and bispecific molecules
Transient expression in HEK293 and CHO systems
Excellent sterile tissue culture technique for routine maintenance of primary and cancer cell lines and subsequent implementation in cell based assays
Good documentation, organization, and communication skills
Highly motivated with ability to work collaboratively in a team environment
Single color or multi-color flow cytometry
Functional protein characterization by ELISA or Octet
Primary cell isolation from blood
Data processing and analysis software (FlowJo, GraphPad Prism, Geneious)
Dren Bio strongly believes in investing in, and rewarding, its employees. This philosophy is embodied in the Company’s total rewards program, which includes competitive cash compensation, equity incentive awards, and employer sponsored benefit offerings. Exact cash and equity compensation shall be commensurate with candidate’s experience and qualifications.
Dren Bio is an equal opportunity employer. Employment decisions are based on merit and business needs. Dren Bio will not discriminate against any job applicant because of race, color, national origin, ancestry, gender, sexual orientation, age, religion, creed, physical or mental disability, gender identity, medical condition, pregnancy, marital status, veteran status, or any other characteristic protected by federal, state or local law.
Please send resume and cover letter to careers@drenbio.com
PDF VersionDren Bio (the “Company”) is a privately held, pre-clinical stage biopharmaceutical company focused on developing therapeutic antibodies for the treatment of cancer, autoimmune and other serious diseases. The Company’s management team and scientific advisors have profound expertise covering the discovery and development of engineered antibodies designed to selectively target and deplete pathological cells. Dren Bio’s pipeline is currently comprised of two distinct programs. The first program surrounds DR-01, the Company’s lead product candidate, which induces antibody-mediated killing of a cell type that is responsible for a multitude of hematologic malignancies and plays a key role in various autoimmune diseases. The Company’s second program is a proprietary antibody-based technology platform, its Targeted Myeloid Engager, which utilizes a novel mechanism of action to selectively engage myeloid cells for the targeted depletion of diseased cells and disease-inducing agents, as well as to induce immunostimulation.
Immunology
Scientist
Foster City, CA
Senior Scientist I, Immunology
Dren Bio is seeking a highly talented and motivated scientist to support our Targeted Myeloid Engager platform for the treatment of solid and hematological cancers. The ideal candidate is an expert in macrophage and/or dendritic cell biology with strong technical experience in probing how myeloid cells contribute to disease pathogenesis or could be restored to treat cancer and inflammatory disease. The candidate will work with a cross-functional team of scientists (immunologists, cell biologists, biochemists, and protein engineers) to advance research stage programs into early clinical development. The candidate will be expected to perform essential ex vivo and in vivo studies to not only assess efficacy of our novel therapeutic agents but to elucidate their impact on macrophage and dendritic cell functions in the tumor microenvironment. Importantly, the successful candidate will be provided necessary training, support, and opportunities to grow into and lead a therapeutic program or project sub-teams, and mentor other researchers.
Work collaboratively with other researchers to advance various therapeutic antibodies in different cancer types
Design, conduct, and interpret high quality ex vivo studies (e.g. ADCC, ADCP, cytokine profiling, gene expression profiling) and in vivo studies (e.g. syngeneic, xenograft, and/or humanized mouse models of cancer) to evaluate efficacy and mechanism of action (MOA) of Dren Bio’s novel therapeutic agents
Specific tasks include animal or human tissue processing, multi-color flow cytometry for immuno-phenotyping, cytokine profiling by MSD or Luminex, ADCC or ADCP assays using Incucyte live-cell imaging and flow cytometry, IHC/IF and confocal microscopy, DNA/RNA extraction for gene expression studies, various biochemical techniques (IP, western blot, IHC, and IF)
Develop and execute assays to evaluate antigen presentation by macrophages and dendritic cells, and T cell activation
Well-versed in various data processing and analysis software (e.g. FlowJo, Prism, ImageJ)
Mentor and train other scientists on novel tools and techniques
Become a project leader for a specific therapeutic program, while demonstrating flexibility and enthusiasm to support evolving company goals that are inherent of a fast-paced start-up environment
Meticulous record-keeping of scientific data, methods, and study designs
Present data in various forums, including lab meetings, department meetings, and multi-functional project teams
Publish scientific and methodological results in high quality journals
PhD in Immunology, Cancer Biology, Biochemistry, or related discipline with approximately 0-3+ years of experience in academia or biopharmaceutical industry.
The candidate is expected to have in-depth training in immunology and rich technical expertise in cellular and molecular immunology
Routine literature search and keeping up to date of the competitive landscape of immuno-oncology
Strong expertise in animal or human tissue processing and downstream assays (i.e. immuno-phenotyping by multi-color flow cytometry, immunohistochemistry, cell-based functional assays, biochemical assays)
Hands-on experience in designing and executing in vivo studies (e.g. syngeneic, xenograft, PDX, humanized mouse models of immuno-oncology)
Proficiency in IP, IV, SC and PO dosing, blood and tissue collection are required
Experience with primary cell isolation and culture
Must have a record of successful scientific accomplishments as evidenced by one or more first-author papers published or accepted in a well-recognized and peer-reviewed journals
Strong analytical and critical thinking skills with the ability to interpret complex data and highly motivated to learn and support the drug development efforts
Motivated self-starter who can work independently and collaboratively in a dynamic team environment with a proactive attitude
Excellent written and verbal communication skills
Ability to work in a fast-paced environment and the flexibility to align daily work with project needs
Ability to set goals and prioritize tasks and resources to achieve superior work quality and efficiency
Must be well organized, have a strong work ethic, attention to detail and be diligent in data documentation
Dren Bio strongly believes in investing in, and rewarding, its employees. This philosophy is embodied in the Company’s total rewards program, which includes competitive cash compensation, equity incentive awards, and employer sponsored benefit offerings. Exact cash and equity compensation shall be commensurate with candidate’s experience and qualifications.
Dren Bio is an equal opportunity employer. Employment decisions are based on merit and business needs. Dren Bio will not discriminate against any job applicant because of race, color, national origin, ancestry, gender, sexual orientation, age, religion, creed, physical or mental disability, gender identity, medical condition, pregnancy, marital status, veteran status, or any other characteristic protected by federal, state or local law.
Please send resume and cover letter to careers@drenbio.com.
PDF VersionDren Bio (the “Company”) is a privately held, pre-clinical stage biopharmaceutical company focused on developing therapeutic antibodies for the treatment of cancer, autoimmune and other serious diseases. The Company’s management team and scientific advisors have profound expertise covering the discovery and development of engineered antibodies designed to selectively target and deplete pathological cells. Dren Bio’s pipeline is currently comprised of two distinct programs. The first program surrounds DR-01, the Company’s lead product candidate, which induces antibody-mediated killing of a cell type that is responsible for a multitude of hematologic malignancies and plays a key role in various autoimmune diseases. The Company’s second program is a proprietary antibody-based technology platform, its Targeted Myeloid Engager, which utilizes a novel mechanism of action to selectively engage myeloid cells for the targeted depletion of diseased cells and disease-inducing agents, as well as to induce immunostimulation.
Protein Sciences
Research Associate I
Foster City, CA
Scientist II, Protein Sciences
Dren Bio is seeking an outstanding, highly motivated individual to support protein production for our discovery programs. The successful candidate will be a member of the Protein Sciences team and support protein production utilizing mammalian protein expression, purification, and characterization. This position offers excellent potential for contribution and visibility at an early-stage company and opportunities for career development. This is a Temp to Hire position.
As an integral member of the Protein Sciences group, this individual will work closely with other team members and partner with other functional areas in the organization
Production of proteins for Research and pre-clinical activities
Protein expression in mammalian system in transient and stable format
Protein purification using affinity and other chromatography methods
Cryopreservation of cell lines and clarification of production medium
Protein quantification, SDS-PAGE, size exclusion HPLC, other analytical methods as appropriate
Materials management and inventory maintenance
Maintenance of electronic lab notebook and databases, preparation of reports, and regular presentations to summarize results and update management
BS degree in biological sciences (biochemistry, cell biology, molecular biology) with 1-3 years experience in the biopharmaceutical industry
Familiarity with mammalian protein expression systems in transient and stable formats, protein purification of monoclonal antibody and other proteins using affinity and other chromatography techniques
Proficiency in aseptic technique, cell line maintenance, and host cell transfection
Experience with analytical methods such as SDS-PAGE, size exclusion HPLC, ELISA, Octet and other methods for protein characterization
Capacity for learning new techniques and handling diverse tasks concurrently
Ability to collaborate and communicate well with colleagues
Ability to work independently or with limited direct supervision
The ideal candidate will be meticulous, highly organized, pay great attention to detail, deliver consistent results, and work under aggressive timelines
The ideal candidate will have strong technical aptitude for lab and instrument work, and a problem-solving mindset that is diligent and flexible
Dren Bio strongly believes in investing in, and rewarding, its employees. This philosophy is embodied in the Company’s total rewards program, which includes competitive cash compensation, equity incentive awards, and employer sponsored benefit offerings. Exact cash and equity compensation shall be commensurate with candidate’s experience and qualifications.
Dren Bio is an equal opportunity employer. Employment decisions are based on merit and business needs. Dren Bio will not discriminate against any job applicant because of race, color, national origin, ancestry, gender, sexual orientation, age, religion, creed, physical or mental disability, gender identity, medical condition, pregnancy, marital status, veteran status, or any other characteristic protected by federal, state or local law.
Please send resume and cover letter to careers@drenbio.com
PDF VersionDren Bio (the “Company”) is a privately held, pre-clinical stage biopharmaceutical company focused on developing therapeutic antibodies for the treatment of cancer, autoimmune and other serious diseases. The Company’s management team and scientific advisors have profound expertise covering the discovery and development of engineered antibodies designed to selectively target and deplete pathological cells. Dren Bio’s pipeline is currently comprised of two distinct programs. The first program surrounds DR-01, the Company’s lead product candidate, which induces antibody-mediated killing of a cell type that is responsible for a multitude of hematologic malignancies and plays a key role in various autoimmune diseases. The Company’s second program is a proprietary antibody-based technology platform, its Targeted Myeloid Engager, which utilizes a novel mechanism of action to selectively engage myeloid cells for the targeted depletion of diseased cells and disease-inducing agents, as well as to induce immunostimulation.
Analytical & Formulation Development
Research Associate I
Foster City, CA
Scientist II, Protein Sciences
Dren Bio is seeking a highly motivated individual to support the protein/antibody characterization needs for all discovery and development for the Company’s pipeline programs. The successful candidate will work as a bench scientist in the Analytical & Formulation Development department and contribute to the analytical method development and formulation needs of the company. This position offers excellent potential for contribution and visibility at an early-stage company and opportunities for career development. This is a Temp to Hire position.
Routinely run HPLC (SE-HPLC), capillary electrophoresis (Reduced and Non-reduced), icIEF, and ELISA based analytical methods for protein/ antibody characterization.
Help develop the above methods for all the molecules in Dren’s pipeline.
Work closely with colleagues in Process Sciences to ensure timely analytical support for cell line, process, and formulation development.
Facilitate the development of SOPs for various analytical methods and the qualification of methods required for technical transfer to CMO/CRO facilities.
Maintain and troubleshoot analytical instrumentation, as required.
Troubleshoot assay performance, as needed.
Document experimental work in electronic lab notebooks, author SOPs, reports.
Communicate results in group meetings.
BS degree in biological sciences (biochemistry, cell biology, molecular biology) with 0-6 months experience in the biopharmaceutical industry
Hands-on knowledge of technical scientific principles for most of the following analytical techniques: HPLC/UPLC (reverse phase, ion exchange, size exclusion), capillary electrophoresis (reduced and non-reduced CE-SDS), charge heterogeneity (icIEF), ELISAs
Strong analytical and critical thinking skills with the ability to interpret obtained results/data
Highly motivated to learn and support the drug development efforts at Dren Bio
Motivated self-starter who can work independently and collaboratively in a dynamic team environment
Excellent written and verbal skills
Ability to work in a fast-paced environment and the flexibility to align daily work with project needs
Must be well organized, have a strong work ethic with attention to details, and diligent in data documentation.
Dren Bio strongly believes in investing in, and rewarding, its employees. This philosophy is embodied in the Company’s total rewards program, which includes competitive cash compensation, equity incentive awards, and employer sponsored benefit offerings. Exact cash and equity compensation shall be commensurate with candidate’s experience and qualifications.
Dren Bio is an equal opportunity employer. Employment decisions are based on merit and business needs. Dren Bio will not discriminate against any job applicant because of race, color, national origin, ancestry, gender, sexual orientation, age, religion, creed, physical or mental disability, gender identity, medical condition, pregnancy, marital status, veteran status, or any other characteristic protected by federal, state or local law.
Please send resume and cover letter to careers@drenbio.com
PDF Version